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Molecular Docking of Inhibitory Activities of Syzygium Cordatum against Mycobacterium Tuberculosis
Molecular Docking of Inhibitory Activities of Syzygium Cordatum against Mycobacterium Tuberculosis

Omolara Olubunmi Adeboye; Francis Oretayo Oyeleke; Saheed Alabi Agboluaje

Volume 5, Issue 2 , April 2022, , Pages 147-163

http://dx.doi.org/10.22034/ajca.2022.310927.1286

Abstract
  Tuberculosis remains a significant infectious disease-causing over 1.8 million deaths a year, making it one of the world’s most deadly human pathogens. Phytochemicals from natural ...  Read More
In-Silico Design, Molecular Docking and Pharmacokinetics Studies of Some Tacrine Derivatives as Anti-Alzheimer Agents: Theoretical Investigation
In-Silico Design, Molecular Docking and Pharmacokinetics Studies of Some Tacrine Derivatives as Anti-Alzheimer Agents: Theoretical Investigation

Abduljelil Ajala; Adamu Uzairu; Gideon Adamu Shallangwa; Stephen Eyije Abechi

Volume 5, Issue 1 , January 2022, , Pages 59-69

http://dx.doi.org/10.22034/ajca.2022.321171.1292

Abstract
  Alzheimer's disease (AD) is a neurodegenerative ailment that affects many people worldwide. Its cause has yet to be determined. One of the symptoms of AD is the loss of cholinergic ...  Read More
Investigation of Amino Chalcone Derivatives as Anti-Proliferative Agents against MCF-7 Breast Cancer Cell Lines-DFT, Molecular Docking and Pharmacokinetics Studies
Investigation of Amino Chalcone Derivatives as Anti-Proliferative Agents against MCF-7 Breast Cancer Cell Lines-DFT, Molecular Docking and Pharmacokinetics Studies

Oluwatoba Emmanuel Oyeneyin; Toluwalope Gbemileke Abayomi; Nureni Ipinloju; Eric Bamidele Agbaffa; Daniel Dada Akerele; Oluwatobiloba Amusa Arobadade

Volume 4, Issue 4 , July and August 2021, , Pages 288-299

http://dx.doi.org/10.22034/ajca.2021.285869.1261

Abstract
  Breast cancer is one of the most lethal diseases that has resulted in many deaths in the world. Development of new compounds and repurposing of approved drugs have become very attractive ...  Read More
Synthesis and Molecular Docking Studies of Some Thiohydantoin Derivatives as Potential Anticancer and Antimicrobial Agents
Synthesis and Molecular Docking Studies of Some Thiohydantoin Derivatives as Potential Anticancer and Antimicrobial Agents

Aysha Belgasem Mezoughi †; Wanisa Abdussalam-Mohammed; Ashraf Ahmed Ali Abdusalam †

Volume 4, Issue 4 , July and August 2021, , Pages 327-338

http://dx.doi.org/10.22034/ajca.2021.291823.1266

Abstract
  2-Thiohydantoin derivatives are most remarkably known because of their extensive applications including, hypolipidemic, anticarcinogenic, antimutagenic, antifungal, and antibacterial. ...  Read More
Evaluation of Medicinal Effects of Isoxazole Ring Isosteres on Zonisamide for Autism Treatment by Binding to Potassium Voltage-Gated Channel Subfamily D Member 2 (Kv 4.2)
Evaluation of Medicinal Effects of Isoxazole Ring Isosteres on Zonisamide for Autism Treatment by Binding to Potassium Voltage-Gated Channel Subfamily D Member 2 (Kv 4.2)

Mehdi Nabati; Vida Bodaghi-Namileh

Volume 3, Issue 4 , July and August 2020, , Pages 462-472

http://dx.doi.org/10.33945/SAMI/AJCA.2020.4.8

Abstract
  The present research study discusses discovery of the novel drugs based on Zonisamide (FDA-approved drug) to treat the autism disease. We designed novel compounds by changing the pyrazole ...  Read More
Molecular Modeling of 3-(1,3-Dioxoisoindolin-2-yl)benzyl Nitrate and its Molecular Docking Study with Phosphodiesterase-5 (PDE5)
Molecular Modeling of 3-(1,3-Dioxoisoindolin-2-yl)benzyl Nitrate and its Molecular Docking Study with Phosphodiesterase-5 (PDE5)

Mehdi Nabati; Vida Bodaghi-Namileh

Volume 3, Issue 1 , January 2020, , Pages 58-69

http://dx.doi.org/10.33945/SAMI/AJCA.2020.1.7

Abstract
  In this study, the electronic properties of the novel medicinal compound 3-(1,3-dioxoisoindolin-2-yl) benzyl nitrate as a treatment of sickle cell disease are obtained using density ...  Read More