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Chemoinformatic Design of Phthalazinone Analogues as Novel Dengue Virus NS2B-NS3 Protease Inhibitors with Enhanced Pharmacokinetics
Chemoinformatic Design of Phthalazinone Analogues as Novel Dengue Virus NS2B-NS3 Protease Inhibitors with Enhanced Pharmacokinetics

Samuel Ndaghiya Adawara; Gideon Shallangwa Adamu; Paul Andrew Mamza; Ibrahim Abdulkadir

Volume 5, Issue 2 , April 2022, , Pages 175-189

http://dx.doi.org/10.22034/ajca.2022.322426.1297

Abstract
  Dengue fever is the most common and important arthropod-borne viral illness in humans. However, no effective medications or vaccinations exist to prevent this condition. The dengue ...  Read More
In-Silico Design, Molecular Docking and Pharmacokinetics Studies of Some Tacrine Derivatives as Anti-Alzheimer Agents: Theoretical Investigation
In-Silico Design, Molecular Docking and Pharmacokinetics Studies of Some Tacrine Derivatives as Anti-Alzheimer Agents: Theoretical Investigation

Abduljelil Ajala; Adamu Uzairu; Gideon Adamu Shallangwa; Stephen Eyije Abechi

Volume 5, Issue 1 , January 2022, , Pages 59-69

http://dx.doi.org/10.22034/ajca.2022.321171.1292

Abstract
  Alzheimer's disease (AD) is a neurodegenerative ailment that affects many people worldwide. Its cause has yet to be determined. One of the symptoms of AD is the loss of cholinergic ...  Read More