CiteScore: 5.0     h-index: 22

Exploration of Anticancer Potential of Novel Pyrrolo[2,3-b]pyridine Derivatives Targeting V600E-BRAF Kinase: Molecular Docking, Pharmacokinetic and DFT Studies
Exploration of Anticancer Potential of Novel Pyrrolo[2,3-b]pyridine Derivatives Targeting V600E-BRAF Kinase: Molecular Docking, Pharmacokinetic and DFT Studies

Abdullahi Bello Umar; Adamu Uzairu

Volume 5, Issue 4 , October 2022, , Pages 271-286

https://doi.org/10.22034/ajca.2022.356191.1322

Abstract
  V600E-BRAF mutation has been detected in several malignant tumours. Developing potent V600E-BRAF inhibitors is considered an essential step in curing diverse cancer types. In this work, ...  Read More
In Silico Identification of Some Novel Ketoamides as Potential Pan-Genotypic HCV NS3/4A Protease Inhibitors with Drug-Likeness, Pharmacokinetic ADME Profiles and Synthetic Accessibility Predictions
In Silico Identification of Some Novel Ketoamides as Potential Pan-Genotypic HCV NS3/4A Protease Inhibitors with Drug-Likeness, Pharmacokinetic ADME Profiles and Synthetic Accessibility Predictions

Stephen Ejeh; Adamu Uzairu; Gideon Adamu Shallangwa; Stephen Eyije Abechi; Muhammad Tukur Ibrahim

Volume 5, Issue 3 , July 2022, , Pages 197-207

https://doi.org/10.22034/ajca.2022.329332.1302

Abstract
  Hepatitis C virus (HCV) infection promotes death rates worldwide. As a result, there is a constant need to improve current HCV therapy and produce new drugs. The NS3/A4 enzyme plays ...  Read More