TY - JOUR ID - 105996 TI - Conventional and Microwave-Assisted Synthesis, Antimicrobial and Antitumor Studies of Tridentate Schiff Base Derived from O-vanillin and Phenyl Urea and its Complexes JO - Advanced Journal of Chemistry, Section A JA - AJCA LA - en SN - 2645-7768 AU - Hassan, Ali Mostafa AU - Osman said, Ahmed AU - Heakal, Bassem Hussien AU - Younis, Ahmed AU - Abdelmoaz, Miral Ahmed AU - Abdrabou, Mahmoud Mohamed AD - Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Egypt AD - Senior Researcher Chemist, Greater Cairo Water Company, Cairo, Egypt AD - Research Laboratory, Cairo Oil Refining Company, Mostorod, Kaliobia, Egypt AD - Green Chemistry Department, National Research Centre, 33 El Bohouth St. (former EL Tahrir St.)-Dokki-Giza-Egypt-P.O.12622 AD - Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University, North Sinai, Egypt AD - Drugs Expert in the Central Administration of Chemical Laboratories Forensic Medicine, Cairo, Egypt Y1 - 2020 PY - 2020 VL - 3 IS - Special Issue SP - 621 EP - 638 KW - Microwave synthesis KW - Metal complexes KW - Schiff base KW - O-vanillin KW - Phenyl urea KW - Thermal analysis KW - HCT-116 KW - MCF-7 DO - 10.22034/ajca.2020.105996 N2 - A tridentate Schiff base ligand (E)-1-(2-hydroxy-3-methoxybenzylidene)-3-phenylurea derived from o-vanillin and phenyl urea in 1:1 molar ratio. Also, the metal complexes of Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) were synthesized using the microwave-assisted irradiation and conventional methods. The ligand and its complexes 1-6 were characterized using the elemental analysis, FT-IR, UV-vis, 1HNMR, mass spectroscopy as well as thermo-gravimetric analysis (TGA). The geometry structures of the complexes were confirmed using electronic spectra, electron spin resonance (ESR) and magnetic moment. Study of the thermal dehydration and decomposition of the Co (II), Ni (II), and Zn (II) complexes kinetically using the integral method applying the Coats–Redfern and Horowitz Metzger equation. The ligand and its metal complexes were screened for the antimicrobial activity against the gram-positive, gram-negative bacteria and fungi also, the cytotoxic activity was evaluated against two cell lines; human colon carcinoma (HCT-116) and breast carcinoma cells (MCF-7). UR - http://www.ajchem-a.com/article_105996.html L1 - http://www.ajchem-a.com/article_105996_4c5e68769def1e722475fdbc2b503578.pdf ER -