Conventional and Microwave-Assisted Synthesis, Antimicrobial and Antitumor Studies of Tridentate Schiff Base Derived from O-vanillin and Phenyl Urea and its Complexes

Hassan, Ali Mostafa; Osman Said, Ahmed; Heakal, Bassem Hussien; Younis, Ahmed; Abdelmoaz, Miral Ahmed; Abdrabou, Mahmoud Mohamed

doi:10.22034/ajca.2020.105996

Document Type : Original Research Article

Authors

¹ Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Egypt

² Senior Researcher Chemist, Greater Cairo Water Company, Cairo, Egypt

³ Research Laboratory, Cairo Oil Refining Company, Mostorod, Kaliobia, Egypt

⁴ Green Chemistry Department, National Research Centre, 33 El Bohouth St. (former EL Tahrir St.)-Dokki-Giza-Egypt-P.O.12622

⁵ Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University, North Sinai, Egypt

⁶ Drugs Expert in the Central Administration of Chemical Laboratories Forensic Medicine, Cairo, Egypt

https://doi.org/10.22034/ajca.2020.105996

Abstract

A tridentate Schiff base ligand (E)-1-(2-hydroxy-3-methoxybenzylidene)-3-phenylurea derived from o-vanillin and phenyl urea in 1:1 molar ratio. Also, the metal complexes of Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) were synthesized using the microwave-assisted irradiation and conventional methods. The ligand and its complexes 1-6 were characterized using the elemental analysis, FT-IR, UV-vis, ¹HNMR, mass spectroscopy as well as thermo-gravimetric analysis (TGA). The geometry structures of the complexes were confirmed using electronic spectra, electron spin resonance (ESR) and magnetic moment. Study of the thermal dehydration and decomposition of the Co (II), Ni (II), and Zn (II) complexes kinetically using the integral method applying the Coats–Redfern and Horowitz Metzger equation. The ligand and its metal complexes were screened for the antimicrobial activity against the gram-positive, gram-negative bacteria and fungi also, the cytotoxic activity was evaluated against two cell lines; human colon carcinoma (HCT-116) and breast carcinoma cells (MCF-7).

Graphical Abstract

Keywords

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Advanced Journal of Chemistry, Section A

Conventional and Microwave-Assisted Synthesis, Antimicrobial and Antitumor Studies of Tridentate Schiff Base Derived from O-vanillin and Phenyl Urea and its Complexes

References

References

Volume 3, Special Issue
September 2020
Pages 621-638

Conventional and Microwave-Assisted Synthesis, Antimicrobial and Antitumor Studies of Tridentate Schiff Base Derived from O-vanillin and Phenyl Urea and its Complexes

References

References

Volume 3, Special IssueSeptember 2020Pages 621-638

Volume 3, Special Issue
September 2020
Pages 621-638