Document Type: Original Research Article

Authors

Inorganic Materials Research Laboratory, Department of Pure and Applied Chemistry, University of Calabar, Nigeria.

Abstract

1-ethyl-3-methylimidazolium acetate (EMIMOAC) and 1-buthyl-3-methylimidazolium acetate (BMIMOAC) ionic liquids have been used as a solvent and stabilizing agent in an attempt to prepare cobalt nanoparticles via chemical reduction method. The SEM and UV-Vis techniques confirm the formation of nanoparticles. XRD reveals the nanocrystalline nature of the products with average crystallite size of 27.5 and 24.1 nm for CoEMIMOAC and CoBMIMOAC, respectively. The SEM and EDAX morphological/atomic weight ratio analyses show not much difference between the nanocrystals formed in EMIMOAC or BMIMOAC. These results indicate that the cationic part of the ionic liquid did not play significant role during nucleation and growth of the particles. The zone of inhibition of CoEMIMOAC obtained against Staphylococcus aureus and Escherichia coli are 23 and 14 mm, respectively whereas that of CoBMIMOAC against the bacterial under investigation is 15 mm. The synthesized nanocrystals have therefore demonstrated great potentials as nanodrugs in the treatment of infections caused by gram-positive microorganisms.

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[1]. P.B. Ashishie, B.E. Inah, A.A. Ayi.  Int. J. Sci., 2018, 7, 25-31.

[2]. A.A. Ayi, C.A. Anyama, and V. Khare. J. Mater., 2015, 2015, 7 pages http://dx.doi.org/10.1155/2015/372716

[3]. F. Endres, S. Z.  El-Abedin. Phys. Chem. Chem. Phys., 2006, 8, 2101–2116.

[4]. S.Z.  El-Abedin, F. Endres. Acc. Chem. Res., 2007, 40, 1106–1113.

[5]. W.M. Reichert, J.D. Holbrey, K. B. Vigour, T.D. Morgan, G.A. Broker, R. D. Rogers, Chem. Commun. 2006, 4767.

[6]. A. Taubert, Acta Chim. Slov. 2005, 52, 183–186.

[7]. A. Taubert, Z. Li, Dalton Trans., 2007, 7, 723–727.

[8]. T. Nakashima, N. Kimizuka, J. Am. Chem. Soc., 2003, 125, 6386–6387.

[9]. A.A. Ayi, V. Khare, P. Strauch, J. Girard, K. M. Fromm, A. Taubert,  Monatsh Chem., 2010 141,1273–1278.

[10]. E.R. Parnham, R.E. Morris, J. Mater. Chem., 2006, 16, 3682–3684.

[11]. E.R Parnham, P.S. Wheatley, R.E. Morris, Chem. Commun., 2006, 380–382.

[12]. D. Marquardt, Z.  Xie, A. Taubert, R. Thomannd and C. Janiak, Dalton Trans., 2011, 40, 8290-8293.

[13]. J. Dupont and J. D. Scholten, Chem. Soc. Rev., 2010, 39, 1780–1804.

[14]. C.S. Consorti, P.A.Z. Suarez, R.F. de Souza, R.A. Burrow, D. H. Farrar, A.J. Lough, W. Loh, L.H. da Silva, J. Dupont J. Phys. Chem. B., 2005, 109, 4341-4349.

[15]. W. Loh, L. H. M. da Silva and J. Dupont, J. Phys. Chem. B, 2005, 109, 4341–4349.

[16]. J. Dupont, J. Braz. Chem. Soc., 2004, 15, 341–350.

[17]. M.-A. Neouze, J. Mater. Chem., 2010, 20, 9593–9607.

[18]. C.B. Murray, C.R. Kagan, M.G. Bawendi, Annu. Rev. Mater. Sci., 2000, 30, 545–610.

[19]. F. Caruso, (ed) Colloids and colloid assemblies. Wiley VCH, Weinheim, 2004.

[20]. J. Cavalieri, D. Rankin, J. Harbeck, L.R Sautter, S.Y McCarter, S.E. Sharp, H.J Ortez, A.C Spiegel. Manual of antimicrobial susceptibility testing.  American Society for microbiology, Washington. 2005, 12, 53-42.

[21]. A. Guinier, X-Ray Diffraction of Crystals, Imperfect Crystals and Amorphous Bodies; Dover: New York, NY, USA, 1994.

[22].S. Link, M.A. El-Sayed. Annu. Rev. Phys. Chem., 2003. 54, 331–66.

[23]. U. Kreibig, M. Vollmer, Optical Properties of Metal Clusters. Berlin: Springer, 1995.

[24]. M. Kerker, the Scattering of Light and Other Electromagnetic Radiation. New York: Academic, 1969.

[25]. C.F. Bohren, D.R. Huffman, Absorption and Scattering of Light by Small Particles. New York: Wiley, 1983.

[26]. V. Bansal and S. K. Bhargava, Ionic Liquids as Designer Solvents for the Synthesis of Metal Nanoparticles, In Ionic Liquids: Theory, Properties, New Approaches, Alexander Kokorin (Ed.), InTech, 2011.

[27]. C. Hardacre, J.D, Holbrey, S.E.J. McMath, D.T. Bowron, A.K. Soper, J. Chem. Phys. 2003, 118, 273–278.

[28]. S. Tsuzuki, H. Tokuda, K. Hayamizu, M. Watanabe, J. Phys. Chem. B, 2005, 109, 16474–16481.

[29]. F. Endres.  ChemPhysChem, 2002, 3, 144–154.

[30]. J. Dupont, P.A.Z. Suarez. Phys. Chem. Chem. Phys., 2006, 8, 2441-2452.

[31]. M. Antonietti, D. Kuang, B. Smarsly, Y. Zhou. Angew. Chem. Int. Edit., 2004, 43, 4988–4992.

[32]. Y. Zhou. Current Nanoscience, 2005, 1, 35–42.