Issam Mohammad Shakir; Bakr Sadiq Mohammed; Nagham Shakir Turkey
Abstract
An innovative and effective method for continuous flow injection analysis (CFIA) was developed and included in the NAG_4SX3_3D Analyzer. The primary objective of this approach was to ...
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An innovative and effective method for continuous flow injection analysis (CFIA) was developed and included in the NAG_4SX3_3D Analyzer. The primary objective of this approach was to quantify the concentration of loratadine. This study presents a methodology for the quantification of loratadine, an antihistaminic medication, in pharmaceutical formulations. The samples are analyzed using the NAG_4SX3_3D Analyzer, which is a device that combines optical, chemical, electronic, and detection capabilities. The analyzer operates by receiving a cumulative signal, eliminating the need for amplification. The total distance travelled is 760 mm in relation to the variable YZ -mV during a period of time represented by t seconds (measured in mm). The selection was made based on the accurate computation of the energy transducer profile. The relative standard deviations for loratadine are 0.09% at a concentration of 5 m.M and 0.1% at a concentration of 8 m.M for n = 6. The limit of detection (LOD) and limit of quantification were found to be 611.076 ng and 129 μg, respectively, using a stepwise dilution of the lowest concentration on the calibration curve with a sample size of n = 13. The linear range has a correlation coefficient (r) of 0.9989, indicating a strong positive relationship. Additionally, the linearity of this range is measured at 99.79% (R2) and recovery is not less than 96.58%, suggesting a high degree of conformity to a linear model. A comparative analysis was conducted between the outcomes of the suggested methodology and the existing UV-spectrophotometric approach, specifically at a wavelength of 275nm, revealing similar findings.
