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In-silico Design of Oxadiazole Hybrids as Potential Inhibitors of Dengue Virus NS2B-NS3 Protease
In-silico Design of Oxadiazole Hybrids as Potential Inhibitors of Dengue Virus NS2B-NS3 Protease

Samuel Ndaghiya Adawara; Gideon Shallangwa Adamu; Paul Andrew Mamza; Ibrahim Abdulkadir

Volume 5, Issue 2 , April 2022, , Pages 118-137

http://dx.doi.org/10.22034/ajca.2022.320210.1291

Abstract
  This study aimed at designing highly potent dengue virus (DENV) inhibitors targeting the NS2B-NS3 protease from 1,2-benzisothiazol-3(2H)-one-1,3,4-oxadiazole (BTZO) hybrid through quantitative-structure-activity ...  Read More
Chemoinformatic Design of Phthalazinone Analogues as Novel Dengue Virus NS2B-NS3 Protease Inhibitors with Enhanced Pharmacokinetics
Chemoinformatic Design of Phthalazinone Analogues as Novel Dengue Virus NS2B-NS3 Protease Inhibitors with Enhanced Pharmacokinetics

Samuel Ndaghiya Adawara; Gideon Shallangwa Adamu; Paul Andrew Mamza; Ibrahim Abdulkadir

Volume 5, Issue 2 , April 2022, , Pages 175-189

http://dx.doi.org/10.22034/ajca.2022.322426.1297

Abstract
  Dengue fever is the most common and important arthropod-borne viral illness in humans. However, no effective medications or vaccinations exist to prevent this condition. The dengue ...  Read More